At our institution, at least one pair of aerobic/anaerobic blood cultures (BacT/ALERT FA/FN bioMГ©rieux) is drawn and cultured, when BSI is suspected. We acknowledge that the term вЂњattributable mortalityвЂќ is subjected to individual clinical assessment and thus choose to assess both outcomes (all-cause and attributable mortality.Д«lood cultures were processed using BacT/ALERT (bioMГ©rieux, Hazelwood, MO) blood culture system throughout the study period. We understand вЂњattributable mortalityвЂќ as вЂњtotal mortality minus the mortality associated with the underlying disease processвЂќ. The secondary outcome was mortality attributable to P. The primary outcome was all-cause mortality during hospital stay.

Septic shock was defined as sustained hypotension despite adequate fluid replacement requiring vasopressor-support. Immunosuppressive drugs included high-dose corticosteroids (prednisone equivalent of в‰Ґ1 mg/kg body weight in the last 7 days), all types of agents to prevent graft rejection in solid organ or human stem cell/bone marrow transplantation (вЂњHSCTвЂќ) such as calcineurin inhibitors or mycophenolate, and to treat autoimmune diseases with monoclonal antibodies such as tumor necrosis factor О± inhibitors used in the last 3 months. Neutropenia was defined as a count of neutrophils below 1.0x10 9/l. aeruginosa isolate as indicated by susceptibility testing. An empirical combination therapy was deemed to be вЂњadequateвЂќ when the activity of the antimicrobials applied was confirmed by subsequent susceptibility testing.Дefinite combination therapy was defined as administration of two antibiotic agents for at least 48 hours with confirmed activity against the respective P. aeruginosa while results from susceptibility testing were still pending. aeruginosa strain identified was susceptible to the antimicrobial compound prescribed.Д®mpirical combination therapy was defined as administration of two antibiotic agents with presumed activity against P.

aeruginosa BSI treated with definite combination therapy or monotherapy in a large 11-year cohort.Д®mpirical antimicrobial treatment was defined as the antimicrobial regimen administered prior to the diagnosis of bacteremia and while identification and susceptibility testing results were still pending. We aimed to determine differences in mortality of patients with P. However, there is a lack of clinical data supporting the use of two active antibiotic compounds once susceptibility is known.ДЄt our tertiary academic care center, a database of all patients with bloodstream infections has been established. It is well-established that the use of combination therapy increases the likelihood of adequate coverage while the results of antimicrobial susceptibility are still pending. aeruginosa BSI is administered due to different considerations: first, to cover the known or suspected pathogen while results of identification and susceptibility testing are pending, second, to avoid emergence of resistance during treatment and third, due to possible synergistic activity resulting in better clinical outcome. aeruginosa remains and data on survival benefits of different antimicrobial treatment strategies are conflicting. Mortality of bloodstream infections (BSIs) caused by P.

Stata student license pitt